After being killed by the doll-bomb in the original manga series, Alita is resurrected by Desty Nova. The Tipharean scientist reconstructs her brain—bringing forth fragments of her past—and gives her a new body that is able to fully utilize her incredible strength. As she awakens, Alita finds herself in a devastated Tiphares, where a battle between Tiphareans with brain-chips and those without is raging. At the same time, the automatic security system goes on a rampage, killing anything that moves. Last Order takes Alita’s adventures into outer space, as she encounters old associates and meets new faces—both friend and foe—and begins to piece together memories of her past.